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bupropion Range of benefits: [1] May improve abstinence from cocaine or methamphetamine (supported by ASAM/AAAP guidelines)

Dihexa acetate can amplify the binding efficiency of HGF and c-Met receptors in vivo with high affinity, activate downstream Akt and ERK cell survival signaling pathways, inhibit neuronal apoptosis, accelerate the generation of new synaptic structures, and remodel the brain's neural synaptic network structure

To see whether the dimeric macrocycles could stimulate cellular proliferation via activation of the Met signalling pathway, we first used HCC827 cells as a model system

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Funding This work was supported by National Natural Science Foundation of China (81771140), Youth Medical Talent Program of Jiangsu Province (QNRC2016068), and Medical Innovation Team of Jiangsu Province (CXTDA2017030)

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