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Regardless of the isoform transcribed, a pre-pro-peptide is translated, which consists of a Class I or II signal peptide directing secretion, the mature IGF-I peptide, and a C-terminal E-peptide extension 19

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Further, the crystal structure of NLRP3 revealed a disulfide bond between conserved cysteine residues in the inflammasome active site, suggesting redox-sensitive activity (Zhou et al., 2011

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