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These toxicities can affect nearly any organ system but most commonly manifest as dermatologic toxicity, endocrinopathies, and severe autoimmune colitis , which requires prompt recognition and management with systemic corticosteroids

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Furthermore, FXR transcriptionally activates Acsl4 in intestinal epithelial cells (IECs), promoting ferroptosis and subsequently impairing ILC3 function, and can induce Wnt2b in cancer-associated fibroblasts (CAFs) within the tumor stroma, fostering a pro-tumorigenic niche (92, 93)

Aug 2020;10(4):1150-1162

Lipid peroxidation of rat liver microsomes

The doctors were reluctant because Lyme disease is rarely considered as a diagnosis in California