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Im curious what the physiological reasons are for this

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Additional Tips for Safety Choose the right needle size: For intramuscular injections, use a 1 to 1.5-inch, 22-25 gauge needle

* Deep intramuscular injection: - Pigs, calves: 4-6ml/head/day

Published route: Intraperitoneal administration in mice, twice daily (2550 mg/kg)