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In addition, iCAFs inhibited several hallmark pathways, such as the TGF-beta signaling, WNT signaling, Hippo signaling, and mTOR signaling pathways, suggesting the transition of iCAFs to an antitumor phenotype (Figure S10F)

Kleinkauf-Rocha J, Bobermin LD, Machado Pde M, Gonalves CA, Gottfried C, Quincozes-Santos A

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In therapeutics, a drug typically produces numerous effects, but usually only 1 is sought as the primary goal of treatment

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In this way, the concordant changes in the measured proteins could provide insights into the disease pathology
