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We observed that the overall metabolic activity was not compromised (Figure 1B) and an increase in expression of major CYP family members (Figure 1C) with the highest expression at day 3 for CYP2B6 and CYP2C19, at day 7 for CYP1A1, CYP1A2, CYP2C19, and CYP2D6, and at day 14 for CYP3A4 and CYP3A7 (Figure 1D)

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And it regulated up to 500 genes, which targeted at the function of proteins for maintenance of redox balance, detoxifying enzymes, and metabolic enzymes ( The Keap1-Nrf2 pathway is the principal protective response to oxidative and electrophilic stresses

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