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In a controlled study of 68-year-old healthy beagles, a multi-carotenoid-vitamin formulation of 5mg astaxanthin daily showed that it can increase retinal function and decrease the refractive error change after a six-month study

Further studies have found that P53 can inhibit system Xc- uptake of cystine by downregulating the expression of SLC7A11, thereby affecting the activity of GPX4 and resulting in the reduction of antioxidant capacity, ROS accumulation, and ferroptosis 11

doi: 10.1038/s41574-020-00443-4 7 RoepBOPeakmanM

Antioxidant activity and reduction of oxidative stress The inclusion of platelet-rich products in incubation or cryopreservation media consistently elevates antioxidant enzyme levelssuch as GSH, TAC, GPx, and SODand reduces lipid peroxidation marker MDA [26, 44, 49, 50, 52, 53, 56]

Direct 5HP2O functionalisation on N-terminally introduced charged amino acids (Glu or Arg in P1, P3) was not possible

The PCR products were then fused into the pEASY-Blunt cloning vector (TransGen, Beijing, China) for sequencing confirmed with five independent clones