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Gastrointestinal disorders (mainly diarrhea): 22.9% vs
This indicates that upregulation of endogenous polyamines, especially putrescine, serves as a critical mediator in BBB injury
GPx-1 can be irreversibly inactivated in vivo , as shown in recent studies of human isolated red blood cells (RBC)

Thirdly, sub-inhibitory drug exposure can significantly upregulate the expression of ERG family, drug efflux pump genes, and stress tolerance genes in C
These all severely affect endothelium function
