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However, a large group notices fatigue that accumulates faster than it should, sleep that degrades when a phone is on the nightstand, and headaches that improve suspiciously when they travel somewhere remote

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Takuma K, Hara Y, Kataoka S, Kawanai T, Maeda Y, Watanabe R, et al

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Hrd1 can recognize and bind NRF2, directing it to the ERAD pathway for ubiquitination and proteasomal degradation [55]