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After the initiation of folic acid fortification, mean plasma folate concentrations increased from 4.6 to 10 ng/mL, homocysteine concentrations fell from 10.1 to 9.4 mol/L, and the prevalence of homocysteine levels above 13 mol/L dropped from about 19% to about 10%

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There is also an increase in excitotoxicity, altered proteasomal function, production of oxidative damage, and metabolic alterations, due to the accumulation of mutated huntingtin inside cells (Cattaneo et al., Melatonin and Its Relationship with Aging As noted, aging is closely related to mitochondrial dysfunction while long-term treatment of aged rats with melatonin enhanced mitochondrial function by both preventing the opening of permeability transition pore in the inner mitochondrial membrane and retaining the cytochrome c and 2,3-cyclic nucleotide 3-phosphodiesterase inside mitochondria, thus providing protein protection against harmful effects of 2,3-cAMP (Baburina et al., 2017