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It isn't ethical to give a placebo to a group of people who really need treatment for cancer

Iron homeostasis is vital for cell survival and iron overload disrupts this balance, thereby inducing ferroptosis (Fig

Compared to placebo (3.3%, 3.2 kg), patients lost a mean of 13.4% (13.5 kg) of body weight in the 10 mg group and 15.7% (15.6 kg) of body weight in the 15 mg group

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EMBO J 27:12661276 Lagirand-Cantaloube J, Cornille K, Csibi A, Batonnet-Pichon S, Leibovitch MP, Leibovitch SA (2009) Inhibition of atrogin-1/MAFbx mediated MyoD proteolysis prevents skeletal muscle atrophy in vivo