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Before fixation, HCK cells were stimulated for 24 h with 5 ng/ml human recombinant transforming growth factor beta 1 (TGF1, ab50036, Abcam, Cambrigde, United Kingdom), 10 mol/l capsazepine (CPZ), 1 mmol/l L-carnitine, 5 ng/ml TGF1 plus 10 mol/l CPZ, whereas 5 ng/ml TGF1 plus 1 mmol/l L-carnitine with Dulbeccos Modified Eagle Medium (DMEM) served as a control

Acylcarnitine profile Metabolites that are abnormal in VLCAD deficiency patients are usually C12, C14, C14:1, C14:2 and C16 [43], with C14:1 accumulation as most important marker, which is derived from partial breakdown of oleic acid (C18:1w9)

Krieger, Alex D

Clinical implications LDL-C, which is responsible for transporting cholesterol to cells, has target levels defined on the basis of CVD risk categories, and these values are periodically updated

M.AlonsoA

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