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10.2741/4679 [Google Scholar] Mishra S, Maurya VK, Kumar S, Ankita AK, Saxena SK (2020) Clinical management and therapeutic strategies for the thyroid-associated ophthalmopathy: current and future perspectives

Whereas other NADPH-dependent oxidoreductases expressed in the livers lacking TrxR1, such as carbonyl reductases or NADPHquinone dehydrogenase 20,23 , might contribute to redox homeostasis in the TR/GR-null livers by reducing non-sulfur substrates, our results suggest that disulfide-reducing activities in TR/GR-null livers are not markedly supported by processes other than de novo GSH synthesis

They serve crucial functions in maintaining a balance by restraining the release of pro-inflammatory cytokines and managing oxidative stress

Exercise: Moderate physical activity upregulates antioxidant enzyme expression

Friedmann Angeli J, Schneider M, Proneth B et al (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice