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Therefore, targeting the involvement of NRF2-GPX2-NOTCH3 axis holds potential as a therapeutic strategy for treating HNSCC characterized by NRF2 activation

No teratogenic effects were observed in studies performed in rats and mice at doses up to 100 mg/kg, which is 24 times the maximum recommended human daily dose (MRHD) on a mg/kg basis and 4 times (rats) and 2 times (mice) the MRHD on a mg/m2 basis

Finally, although enzymatically inactive mutants of Ceg14 interacts with actin indistinguishably to wild-type protein, they have lost the ability to inhibit actin polymerization (Fig

Reduced Egfr expression was confirmed in granulocytes and macrophages sorted from AOM/DSS tumors (Fig