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GPx deficiency results in direct tissue damage and activation of age-related NF-B inflammatory pathways, which is associated with aging

This timeline is slightly slower than tirzepatide at equivalent points in the dose escalation, but the endpoint results at maximum tolerated doses are closer than many people expect

Conversely, copper can also induce cytotoxicity through ROS accumulation and high mitochondrial-dependent energy metabolism, in a process called cuproptosis (374, 375)