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Prokinetic agents such as metoclopramide or domperidone, which accelerate gastric emptying, may counteract some of the therapeutic effects of semaglutide on satiety and weight loss

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Not specific to IGF-1 LR3 but pathway-relevant

Two different conditions were employed: endpoint A, where the medium was supplemented with an excipient (citrate-phosphate buffer, pH 5, Merck, Darmstadt, Germany), and endpoint B, where the medium was supplemented with cyanocobalamin (Merck) at a final concentration of 1 nM