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The results of a follow-up trial of ARA 290 (20) administered intravenously three times weekly for 4 wks to sarcoidosis patients with symptoms of small-fiber neuropathy also appeared to be safe and was associated with a significant improvement in the patient-reported outcomes of the small-fiber neuropathy screening list (SFNSL) (21) and the pain and well-being components of the RAND-36
Doses above 100mg daily show diminishing returns in NNMT inhibition the enzyme inhibition curve plateaus beyond 150mg while increasing the risk of methylation pathway disruption and homocysteine elevation

3.Measure the dosage accurately to avoid overdosing or underdosing

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2.2 Parallel artificial membrane permeability assay (PAMPA) Passive membrane transport properties were measured using a 96-well pre-coated PAMPA plate system with membrane pore size 0.4 m (Gentest, Corning
