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PubMed Malinda KM, Sidhu GS, Mani H, et al

Even then, elevated uric acid may contribute to hypertension, insulin resistance, or liver fat buildup acting as an amplifier rather than the root cause

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In addition to its direct antitumor effects, daratumumab exerts an indirect immunomodulatory role by eliminating CD38 + immunosuppressive cell types (Treg, Breg and myeloid-derived suppressor cells) in the tumor microenvironment (TME), thereby promoting T-cell proliferation and effector functions [44]
