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The dosing ramps up across the first cycle: Days 1 through 15: 4 units (1 mg/day) Days 16 through 30: 8 units (2 mg/day) After 30 days, patients take 30 days off before starting the next cycle

Downstream signalling pathways (such as MAPK and PI3K), which regulate HGF/c-MET-induced effects on cancer cells and endothelial cells, 11,13,16 are not activated, preventing cell proliferation and migration/invasion, and reducing growth factor and cytokine secretion (which in turn interrupts further activation of PSCs)

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