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While NNMT indirectly influences NAD+ levels, they are not the same

However, in megaloblastic anaemia caused by B12 or folate deficiency, the picture is more complex

In addition, amino acids also serve as precursors of many important metabolites that regulate gene expression, post-translational modifications of proteins, cell fate, etc

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Treatment with picomolar to nanomolar concentrations of Dihexa produces dose-dependent increases in spine density, with maximal effects observed at 10-12 M concentrations