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A phase 2 study reported an improved median overall survival (mOS) when nimotuzumab was combined with radiation in patients with high-grade glioma, showing a mOS of 17.76 months compared to 12.63 months in the placebo plus radiation group ( Recent preclinical studies utilizing in vitro glioblastoma stem cells (GCS) models and GB orthotopic xenograft model with EGFR variant III showed antitumor activity along with inhibition of EGFR downstream signaling pathway for the third-generation EGFR inhibitor osimertinib ( 2.2 Platelet-derived growth factor receptor-targeted agents Imatinib, a drug primarily approved for leukemia, has been explored for its potential in treating rGB with mixed outcomes