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doi: 10.1016/j.rmed.2005.03.038

Lian BL, Wu MF, Feng ZQ, et al

The accumulation of intracellular ROS caused by low levels of tert-butyl hydroperoxide can induce the activation of p53 and lead to cell death, which can be specifically inhibited by the ferroptosis inhibitor Fer-1 but cannot be inhibited by other kinds of cell death pathway inhibitors, indicating that the form of death is ferroptosis

By continuously neutralizing these free radicals, glutathione is thought to prevent systemic inflammation and cellular exhaustion (though the cited study actually evaluates the efficacy of sorafenib on metastatic renal cell carcinoma)

doi: 10.1079/bjn19780152

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