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In contrast, differences in return of symptoms were less consistent across analytic approaches and did not remain significant when accounting for within-patient clustering

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Moreover, the treatment should be able to reach the central nervous system, which is a difficulty for both drugs (must cross the bloodbrain barrier or be administered intrathecally) [263] and devices (surgical access to the CNS might be required)

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By mimicking the action of amylin, cagrilintide may enhance satiety after meals, helping individuals feel fuller for longer periods