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26,43,44 The enzymes UGT (glucouronidation), SULT, CYP 450, GST, N -deacetylase (deacetylation), NAT2 (deacetylation), and fatty acid amide hydrolase are involved in APAP metabolism and have been shown to be related to both hepatic and nephrotoxic effects of the analgesic medication

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Interestingly, reductions seen after NAC treatment in behavioral studies were accompanied by either restoration in the accumbal x c system [29] or no changes [30]

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