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Puede causar leve enrojecimiento o sensacin temporal
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Typical doses range from 250-1000 mg daily, though clinical evidence supports only modest benefits at lower doses
Total annual exposure is 200 mg
doi: 10.1093/ejendo/lvad044 236 CuiJShenJRuXTianZDuanZChenGet al
451 In streptozotocin (STZ)-induced diabetic rat and mouse models, elevated expression of P2X2 and P2X3 receptors in the DRG, along with increased current density and P2X4 receptor expression on satellite glial cells, indicates that P2X4 receptor activation in the DRG significantly contributes to DPN-induced mechanical pain hypersensitivity (Fig
