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10.3390/toxins7083179 268 SilvaL

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Eicosanoids are involved with intracellular signaling by stimulating GPCRs coupled to G-protein subtypes Gs, Gq and G12/G13
Furthermore, conducting proof-of-concept studies with small molecules, biologics and gene therapies targeting AD-related pathways will further validate the models utility for drug development

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For EdU click labeling, sections were click reacted using a Click&Go EdU 488 imaging kit (Click Chemistry Tools, #1324) according to manufacturer instructions before proceeding with subsequent immunolabeling
