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We show that restricting exogenous GSH by acivicin, while substantially decreases the overall thiol level and extending the lifespan, reduces endogenous GSH only mildly (Fig

64,5 kJ / 15,5 kcal

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NICOTINAMIDE (NAM), NAD+ PRECURSOR: The NAMPT salvage pathway that converts nicotinamide to NAD+ represents the major route to NAD+ biosynthesis in mammals

[DOI] [PubMed] [Google Scholar] Tungsiripat M, Drechsler H, Sarlone C, Amyot K, Laffey E

These studies are particularly noteworthy given that ferroptosis has recently emerged as an attractive therapeutic target for certain cancers [115]