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10.3390/nu12071912 83 ReidM

In a breast cancer xenograft model (MDA-MB-231), mitochondria-targeted nanomedicines co-assembled from berberine and doxorubicin effectively repairs mitochondrial protein defects (Mfn1/Drp1) and inhibits the activity of MMP-2 and MMP-9, resulting in significant suppression of tumor cell proliferation and lung metastasis [242]

The clearest evidence to illustrate the similar physiologic functions has been shown in tumor-associated hypoglycemia induced by the pathophysiologic elevation of insulin 10, 11 or IGF-2 from islet 12 or non-islet tumor cells

doi: 10.1111/j.1365-2672.2012.05344.x 93 DhakalRBajpaiVKBaekKH

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