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AGEs stimulate PTECs to upregulate the expression of IL-6 and intercellular adhesion molecule 1 (ICAM-1), which induce the transmigration of macrophages, lymphocytes and mast cells into the interstitial space (52)

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Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T cell development

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The clustering of the R-domain and Lasso motif also provides a plausible explanation for the inhibitory role of S251 phosphorylation, which is poised to disrupt the R-domain interaction network by charge repulsion (IFwide inhibitedFig