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Additionally, lobetyolin has been found to induce apoptosis in colon cancer cells by inhibiting ASCT2 (He et al., 2020)

Cancers (Basel) 11 (6)

Still, this does not preclude extramitochondrial CHAC1 from concurrently influencing ferroptosis, as we show that CHAC1 loss significantly spares cytosolic GSH under cystine starvation, a significant factor in the capacity of cells to mitigate lipid peroxidation 11

Hepatology 23 , 818827 (1996)

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Thus, our induced increase in cystine entry increases NADPH consumption [27], while slowing the release of cysteine leads to the reduction of iron and genotoxicity [4]