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All other relevant data supporting the key findings of this study are available within the article and its Supplementary Information Files or from the corresponding author upon request

Calpain-2 activation might exacerbate tau pathology as TBI mouse models have revealed calpain-2 activation resulted in increased tyrosine phosphorylation of kinase c-Abl at Tyr245, resulting in increased kinase activity and phosphorylation of tau at Tyr394 (Wang et al., 2017)

doi: 10.3390/toxins11060328

& McQuay, H

Among the macromolecular signaling complexes controlling autophagy AMPK, that is activated by an increase in AMP/ATP ratio, works as a fuel-sensing enzyme and may induce autophagy

10 cases per million people annually in developed countries