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Novel glutathione-dependent thiopurine prodrugs: evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

Taken together, these data showed that HSP90, by forming a complex with Tim-AIII, further targeted and triggered GPX4 ubiquitination and degradation, which in turn induced ferroptosis in NSCLC cells

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The second test is usually a Western blot

Although studies performed in twins with ASD have revealed a high degree of heritability (3854%), several meta-analyses studies have also shown that genetic-independent causes of ASD do exist [2]