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A 2025 Frontiers in Physiology study demonstrated that MOTS-c restores mitochondrial respiration in type 2 diabetic hearts

and international association for the study of obesity

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Also searched were the Agency for Healthcare Research and Quality evidence reports, Clinical Evidence, the Cochrane database, Essential Evidence, the Institute for Clinical Systems Improvement, the National Guideline Clearinghouse database, and the U.S

Zhang J, Wang Y, Li G, Yu H, Xie X (2014) Down-Regulation of Nicotinamide N -methyltransferase Induces Apoptosis in Human Breast Cancer Cells via the Mitochondria-Mediated Pathway

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