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Research indicates that BIPN may arise from the activation of the RAGE/STAT3 signaling pathway in the dorsal horn, which is driven by the accumulation of methylglyoxal

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Normal adults produce approximately 700 mg of uric acid daily (Jalal et al., 2013)

This decrease is thought to represent an adaptive response to reduced carbohydrate availability, as lower insulin and glucose levels impair the activity of deiodinase enzymes (DIO) that convert T4 to active T3 in peripheral tissues [13]

doi: 10.1038/s41586-019-1291-3 Summary Keywords psoriasis, gut microorganisms, metabolites, immunity, diet Citation Zhu Q, Wu K, Yang Q, Meng B, Niu Y and Zhao F (2023) Advances in psoriasis and gut microorganisms with co-metabolites