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(2019) 63:e0023719

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In addition, an in vivo shRNA library screen and validation using CRISPR induced gene deletion revealed that the loss of several p53-regulated DNA repair genes can markedly accelerate c-MYC-driven lymphomagenesis and the removal of Mlh1 , a key gene involved in MMR, can even on its own promote spontaneous tumour development [58]

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