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Growing evidence implicates gut microbiota dysbiosis as a contributing factor, acting through immune, neuroendocrine, and metabolic pathways that may reinforce central sensitization

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Besides bipolar I and II, other subtypes include fast cycling (more than four manic, depressive, hypomanic, or mixed episodes in one year) and cyclothymia (hypomanic and subdepressive symptoms over two years) [43]

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