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147 Additionally, multiple clinical studies have reported the associations between plasma TMAO levels and their dynamic changes and stroke risk, severity, and long-term adverse outcomes

Weger N., Klaassen Z., Sturt C., Hertz S

These anecdotal reports may stem from indirect mechanisms, such as nocturnal hypoglycemia (particularly in combination with insulin or sulfonylureas, where low blood sugar can trigger cold sweats or drenching sweats), rapid weight loss altering metabolism and hormone regulation, dehydration from gastrointestinal side effects, or sleep disruptions

Lipoic acid has also been shown to improve nitric oxide (NO)-dependent vasodilation in aged rats by increasing PKB/Akt-dependent phosphorylation of endothelial NO synthase (eNOS) and eNOS-catalyzed NO production (47)

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Endocrinology 160 , 772781 (2019)
