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Nicotinamide N-methyltransferase (NNMT) is a cytoplasmic enzyme that catalyzes the methylation of nicotinamide (NAM) with the methyl donor S-adenosyl-methionine (SAM) to form methylnicotinamide (MNAM) and S-adenosyl-l-homocysteine (SAH) (Van Haren et al., 2016)