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Journal of medicinal chemistry
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Hal Scofield is a physician-scientist at the Oklahoma Medical Research Foundation, and he also serves as associate chief of staff for research at the Oklahoma City VA Medical Center
Excessive ROS damages mitochondrial DNA (mtDNA), proteins, and lipidsfurther impairing ETC function in a vicious cycle
When macrophages and other immune cells engulf pathogens or damaged tissue debris, they generate large amounts of ROS, such as superoxide anions, hydrogen peroxide, via respiratory burst (148)
