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In this review, we describe recent discoveries providing evidence for the contribution of the GHGHRIGF1 axis on mitochondrial biogenesis, mitophagy (or autophagy), and mitochondrial function under multiple physiological conditions

eLife, 14, e12270663

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Research by Savit Malhotra and Quynh Theresa Do

Using the safety and feasibility data from these first-in-human trials demonstrating that intermittent D+Q was well tolerated in 50 subjects (NCT 02874989 and NCT 02848131), combined with the efficacy data in mouse models, we initiated a Phase I study of senolytic therapy in older adults with early-stage symptomatic AD, SToMP-AD (Senolytic Therapy to Modulate the Progression of Alzheimers Disease, NCT04063124) (107)