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The groups most likely to develop B12-related hair and skin changes are the same ones at risk for deficiency generally: vegans and vegetarians, adults over 50, people on long-term metformin or proton pump inhibitors, anyone who's had bariatric surgery, and people on GLP-1 protocols whose reduced appetite has significantly lowered their overall nutrient intake for an extended period

doi: 10.1371/journal.pone.0116008 264 ItoILoucasBDSuzukiSKobayashiMSuzukiF

Some more severe, but rare, side effects that can occur are low potassium levels, muscle cramps, irregular heartbeat, chest pains, or blurred vision

GHK-Cu Dosing: Five Clinical Facts You Need Before Starting The standard GHK-Cu dosage at Perfect B is 1 mg/day (4 units) for days 1-15, escalating to 2 mg/day (8 units) for days 16-30

The injection breaks the spasm cycle at its source rather than masking it systemically with medication