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GSH depletion has been strongly associated with the diseases and loss of function with ageing1

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Real-time quantitative-PCR (qPCR) was then performed using Roche LightCycler 480 with Luna Universal qPCR Master Mix (New England Biolabs, Cat#M3003E)

Studies have confirmed that ferroptosis selective preferentially oxidizes specific polyphosphorylated phosphatidylethanolamine (PE)-containing polyunsaturated fatty acids (PUFAs), such as arachidonic acid (AA) and epinephrine (Kagan et al., 2017), leading to lipid peroxidation in the end, so the lipid peroxidation pathway plays the key role in regulating ferroptosis

J Neurotrauma

[DOI] [PMC free article] [PubMed] [Google Scholar] 272.Wu Y., Meng X., Huang C., Li J