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A 2021 review in Nature Reviews Molecular Cell Biology describes a gradual drop in tissue and cellular NAD+ across aging in rodents and humans, and links that fall to metabolic disease, cognitive decline, and sarcopenia [1]

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doi:10.1007/s00266-019-01466-7 Tijerina JD, Morrison SD, Nolan IT, Vail DG, Lee GK, Nazerali R

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