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Previous studies suggest that the hierarchy of selenoprotein expression is dependent on sequences in the 3 UTR of Sec-gene transcripts, as an exchange of 3 UTRs (including the SECIS elements) among various selenoprotein mRNAs altered their translational efficiency in selenium-depleted cells (30)

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Gaida, I

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10.1152/ajpcell.1996.271.5.C1424 [DOI] [PubMed] [Google Scholar] Bedard K., and Krause K.H

Other limitations of the current secondary analysis include the small number of participating patients and the limited amount of biomarker datapoints, which render our investigation strictly hypothesis generating
