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It all comes down to an enzyme called NNMT

This conclusion was drawn by measuring collagen type I levels produced by fibroblasts in a cell culture following exposure to varying concentrations of AHK

Recent research has broadened its applications beyond metabolism, highlighting its synergistic potential with NAD+ therapy for anti-aging and longevity benefits.[6][7] For instance, studies in adipocytes have demonstrated that 5-Amino-1MQ can increase NAD+ levels by 1.2 to 1.6-fold, suggesting a direct role in cellular rejuvenation.[8] This evidence prompted HyperCharge Health to incorporate NAD+ therapy with 5-Amino-1MQ, particularly for adults over 40, where NAD+ levels may have dropped by 50% or more.[9][10] At our clinics, we've observed patients reporting not just improved energy but also enhanced skin elasticity and reduced inflammation markers after combining these therapies

It has even been proposed that NNMT be considered as a novel and sensitive serum biomarker for detecting colorectal cancer, outperforming the clinical significance of carcinoembryonic antigen (CEA) (42)

One mechanism involves reducing transforming growth factor beta-1 secretion in fibroblasts