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Short-chain fatty acids (SCFAs), commonly present in the gut, act as crucial immunoregulatory metabolites and have demonstrated protective effects in individuals with airway inflammation (40)

Epub 2021 Nov 16

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A total sample size of 40 was chosen because it had greater than 80% power to detect a 4-point difference between groups in Montgomery-Asberg Depression Rating Scale (MADRS) scores over 12 weeks, assuming a standard deviation for repeated measures of MADRS of 6, and a within-subject correlation of 0.6

Accumulation may occur in patients with severe renal impairment who are not receiving dialysis, necessitating careful monitoring

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