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CYP3A4 and CYP3A5 are present in the GIT all regions, and CYP3A4 is highly abundant in the duodenum and jejunum ( Additionally, phase I metabolic enzymes that can participate in oxidation reactions includes flavo-protein monooxygenases (FMO), mono-amine oxidase (MAO), diamine oxidase (DAO) and dehydrogenases (e.g., alcohol dehydrogenases (ADHs) and aldehyde dehydrogenases (ALDHs))