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IGFBPs are widely expressed in most tissues and regulate circulating IGF-1 concentrations through both overlapping and distinct mechanisms, thus influencing IGF-1 activity and signaling (53)

Finnerup N

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Thorel F, Npote V, Avril I, Kohno K, Desgraz R, Chera S, Herrera PL

The peptide consists of 30 amino acids (the first 29 of GHRH plus a modification) with specific chemical alterations that resist enzymatic degradation and prolong receptor activation

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