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10.3233/nre-192942 NeuroRehabilitation 84 YangJ
In the domestic clinical trials, the addition of tolvaptan (7.5 mg/day for 7 days) was more effective than conventional diuretics on ascites in multicenter RCTs for poor responders to standard diuretic therapy (spironolactone at 25 mg/day and furosemide at 40 mg/day or higher, or spironolactone at 50 mg/day or higher and furosemide at 20 mg/day or higher) [116, 117]
Li M, Zhao L, Liu J, Liu A, Jia C, Ma D, et al
Orphanet J Rare Dis 2 , 16 (2007)
H-RDW correlated with age above the mean, colonic location of the lesion, pT and TNM stage
Prospective trials combining ferroptosis inhibitors with neuroprotective agents (such as edaravone) are also needed to explore whether targeting ferroptosis can aid prevention and treatment of PVL in extremely preterm infants
