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Additionally, phenformin is also robust to genetic differences manifest in a wide range of Caenorhabditis species, indicating that it may provide a more optimal scenario with which to elucidate longevity-promoting mechanisms stimulated by biguanides

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Lipotype Lipidomics technology can be used to characterize GPMV or nano plasma membrane vesicles

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This is complicated, however, by the absence of specific pathognomonic histopathological features, and diagnosis may be challenging [34]